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doi:10. 1038/nature02467Spatial interactions in brightness perception are well known1,2 but provide an incomplete description; the TCE shows that brightness is inuenced by temporal context as well. Our results further show a surprising juxtaposition of facts: rst, that information encoded about the brightness of stimuli changes over time, such that the appearance of physically identical brief ashes compared to a persisting long ash varies as a function of stimulus onset asynchrony Fig. 1c; and yet, second, the perceived brightness of a long ash remains constant over time Fig. 2a. This indicates that brightness encoding might involve at least two neural populations: one with an adapting response that diminishes over time, and the other with a downstream response that assigns brightness labels to objects and does not adapt. We propose that the TCE arises from an interaction between these non adapting and adapting encodings. In our model, activity in the non adapting population remains constantthereby encoding an unchanging labeleven while its input from the adapting population diminishes Supplementary Fig. S1; for an example of such hysteresis, see ref. 9. The hypothesis that some neurons maintain a brightness label is consistent with the idea that the brain strives to monitor the external world undistracted by predictable changes in its own physiology.

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1588 Welsh Bible Now Onlinene of the most important books ever published in Welsh has been digitized and is now available on the National Library of Wales' Web site . The 1588 Bible, translated by Bishop William Morgan, contains 1,110 pages and is the first complete Welsh language version of the Bible. Its printing produced a far reaching effect on Wales and its citizens, and proved instrumental in the establishment of loyalty to the Protestant Church of England in Wales. "When the Bible was originally published it marked a revolution in the status of the Welsh language," says Lyn L wis Dafis, the library's metadata manager. "Digitization is ushering in a revolutionary period in the way the library works today and it's only fitting that a volume of such immense influence should also be part of this new revolution" In addition to the 1588 Bible, the library has digitized "A Bible for Wales" by Dr. Prys Morgan, which relates the story of Morgan's translation and its significance in the religious and social context of 16th century Wales. Biomedical Digital Librariesiomedical Digital Libraries is an Open Access, peer reviewed, online journal that considers manuscripts on all aspects of digital library content and usage in biomedical settings, including academic medical centers, research and development institutes, and health care institutions. Biomedical Digital Libraries will provide a forum for the discussion of unique considerations of biomedical information needs, and both opportunities and constraints presented by health care settings. The research results of collaborative initiatives with information technology and informatics partners are appropriate and encouraged. Publication of research articles by Biomedical Digital Libraries is dependent on either scientific validity or analytical coherence, as judged by their reviewers. Biomedical Digital Libraries provides a legitimate alternative to traditional print journals in the field, which have subscription fees and assumption of This journal will stress Open Access to research and practice in biomedical libraries, and will permit rapid and unimpeded dissemination of knowledge.

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